Six antibiotics active against Pseudomonas aeruginosa (antipseudomonal antibiotics):

• Tobramycin (aminoglycosides)
• Amikacin (aminoglycosides)
• Ciprofloxacin (fluoroquinolones)
• Ceftazidime (cephalosporins; third generation)
• Piperacillin/tazobactam (penicillin combination)
• Meropenem (carbapenems)

P.aeruginosa has intrinsic resistance to many common antibiotics, including trimethoprim/sulfamethoxazole (Co-trimoxazole).

To treat infections caused by P.aeruginosa, it’s essential to perform antibiotic susceptibility testing because of the bacterium’s variable resistance patterns.