Stenotrophomonas maltophilia is naturally resistant to a wide variety of commonly used antibiotics:

First-generation cephalosporins (e.g., cefazolin, cefalexin)
Second-generation cephalosporins (e.g., cefoxitin, cefuroxime)
Carbapenems: imipenem, meropenem, ertapenem
Nitrofurantoin
Tetracycline
Kanamycin

Abbreviations:

• AMC amoxicillin/clavulanate (penicillins)
• AMP ampicillin (penicillins)
• ATM aztreonam (monobactams)


• CIP ciprofloxaxin (quinolones) - alternative treatment; should be tested
• COX cefotaxime (ceph. III. generation)
• CPD cefpodoxime (ceph. III. generation)
• CXM cefuroxim (ceph. II. generation)
• CXN cefalexin (ceph. I. generation)
• CZD ceftazidime (ceph. III. generation)


• FEP cefepime (ceph. IV. generation)
• FOX cefoxitin (ceph. II. generation)


• SXT trimethoprim-sulfamethoxazole, Co-trimoxazole (sulfonamides) - the treatment of choice; should be tested


• NFE nitrofurantoin (nitrofurans)